HA PRP Ikusanyamakuru Tube
Ibisobanuro bigufi:
HA ni aside ya hyaluronike, ikunze kwitwa aside hyaluronic, Izina ryuzuye ryicyongereza: aside hyaluronic.Acide Hyaluronic ni iyumuryango wa glycosaminoglycan, igizwe nibice byinshi bya disaccharide.Bizakirwa kandi byangirwe numubiri wumuntu.Igihe cyibikorwa cyacyo ni kirekire kuruta icya kolagen.Irashobora kongera igihe cyibikorwa binyuze mu guhuza, kandi ingaruka irashobora kumara amezi 6-18.
Impinduka nyamukuru ya pathophysiologique yivi osteoarthritis ni ugutakaza karitsiye, kwiyubaka amagufwa ya subchondral, gushiraho osteophyte hamwe na synovial inflammatory reaction.Kugaragara kwa mbere kwa clinique ni kubyimba, kubabara no gukomera kw'ingingo hamwe nuduce dukikije.Iyo ndwara igenda itera imbere, buhoro buhoro biganisha ku mikorere idahwitse kandi bigira ingaruka zikomeye ku mibereho.Ubushakashatsi bwerekanye ko ubumuga bw’abafite ubumuga bwa osteoarthritis ku isi bwari 2,2% mu mwaka wa 2010, kandi umubare w’abafite ubumuga muri uwo mwaka urenga miliyoni 1.7, ibyo bikaba byangiriye nabi sosiyete, imiryango ndetse n’abantu ku giti cyabo.HA ni molekuliyumu nyinshi ya polysaccharide biomaterial ikorwa no guhinduranya inshuro nyinshi aside n-acetylglucuronic.Nibintu nyamukuru bigize flux synovial fluid hamwe nikimwe mubigize matrise ya karitsiye.Ifite uruhare mu mirire no kurinda ingingo.HA mu kuvura osteoarthritis byagaragaye ko ifite uruhare runini mu kugabanya ibimenyetso byo kubabara ivi no kunoza ivi.Ariko, kubera kubura inkunga ishingiye ku bimenyetso, cyane cyane ingaruka zigihe kirekire zitazwi, amabwiriza ya AAOS aheruka yo gusuzuma no kuvura osteoarthritis yo mu ivi ntabwo asaba gukoresha aside hyaluronike, kandi urwego rusabwa rusabwa cyane.Triamcinolone acetonide, nka glucocorticoid ikora igihe kirekire, igira ingaruka zikomeye kandi zirambye zo kurwanya inflammatory.
Uburyo bwayo ni ukubuza fagocytose no gutunganya antigene na macrophage;Gutuza membrane ya lysosomal no kugabanya irekurwa rya hydrolase muri lysosome;Kubuza kwimuka kwa leukocytes na macrophage biva mu mitsi y'amaraso kandi bigabanye kubyutsa umuriro.Ubu bushakashatsi bwerekana ko ingaruka zo gutera inshinge zo mu bwoko bwa acetonide triamcinolone ari nziza mu gihe cy'ukwezi kumwe nyuma yo kuvurwa, ariko hamwe n'igihe cy'izabukuru, cyane cyane nyuma y'amezi 6 yo kwivuza, ingaruka ziri hasi cyane ku yandi matsinda yombi.Mcalindon n'ubundi bushakashatsi bwerekanye ko ku barwayi bafite ibimenyetso barwaye ivi osteoarthritis, gutera inshinge zo mu bwoko bwa triamcinolone acetonide byateje igabanuka ryinshi rya karitsiye kandi nta tandukaniro rikomeye riri mu bubabare bw'ivi ugereranije na saline isanzwe.
Ubushakashatsi bwavuzwe haruguru ntabwo bushigikira ubu buvuzi ku barwayi bafite ibimenyetso bafite osteoarthritis yo mu ivi.Bamwe mu bashakashatsi bakoresheje triamcinolone acetonide na sodium hyaluronate inshinge zo mu nda kugira ngo bavure osteoarthritis yo mu ivi, kandi ingaruka zayo z'igihe gito kandi kirekire ni nziza kuruta iyo aside ya hyaluronike yonyine.Nkumuti mushya, PRP irashobora kuboneka mumaraso yabarwayi ba autologique periferique, nta kwanga ubudahangarwa, kandi ikubiyemo ibintu byinshi bikura.Ibintu byo gukura byagaragaye ko biteza imbere ikwirakwizwa rya chondrocyte hamwe na synthesis ya matrix idasanzwe.Byongeye kandi, ubushakashatsi buherutse gukorwa bwerekanye ko PRP ishobora guhagarika bagiteri yubusa ya synovium ku rugero runaka mugihe iteza chondrocyte kuvugurura.Ubushakashatsi bwinshi bwinyamaswa nubushakashatsi bwamavuriro byerekana imikorere myiza.Ubu bushakashatsi bwerekana ko amanota WOMAC ya PRP mumezi 1 na 3 nyuma yo kuvurwa ahwanye na acide hyaluronic, naho amanota WOMAC ya PRP mumezi 6 nyuma yo kuvurwa aruta ayandi matsinda yombi, byerekana ko ifite a ingaruka nziza zo hagati nigihe kirekire cyo kuvura.Ariko, kubera kubura ubushakashatsi bwigihe kirekire bwo gukurikirana amavuriro manini no kubura inkunga itaziguye ituruka kubindi binyabuzima bya molekuline cyangwa amashusho ya MRI, haracyakenewe ubushakashatsi n’ibiganiro.
