GFs na molekile ya bioactive igaragara muri PRP iteza imbere ibikorwa 4 byingenzi mubidukikije byubuyobozi, nko gukwirakwiza, kwimuka, gutandukanya selile, na angiogenez.Cytokine zitandukanye na GF bigira uruhare mugutunganya imisatsi ya morfogenezi no gukura kwimisatsi.
Ingirabuzimafatizo ya dermal (DP) itanga GF nka IGF-1, FGF-7, gukura kwa hepatocyte, hamwe no gukura kw'imitsi iva mu mitsi ishinzwe kubungabunga umusatsi mu gice cya anagen cyizunguruka ry'umusatsi.Kubwibyo, intego ishobora kuba iyo kugenzura GF muri selile DP, ikagura icyiciro cya anagen.
Nk’uko ubushakashatsi bwakozwe na Akiyama et al bubitangaza, ikintu cyo gukura epidermal no guhindura imikurire bigira uruhare mu kugenzura imikurire n’itandukanyirizo ry’ingirabuzimafatizo, kandi ibintu bikura bikomoka kuri platine bishobora kugira imirimo ifitanye isano n’imikoranire hagati y’ibibyimba hamwe n’imitsi bifitanye isano, guhera kuri follicle morphogenez.
Kuruhande rwa GFs, icyiciro cya anagen nacyo gikoreshwa na Wnt / β-catenin / T-selile factor lymphoid.Mu ngirabuzimafatizo za DP, gukora kwa Wnt bizatuma habaho kwirundanya β-catenin, iyo, ifatanije na T-selile factor lymphoide yongera imbaraga, nayo ikora nk'abafatanyabikorwa ba transcription kandi igatera ikwirakwizwa, kubaho, na angiogenez.Utugingo ngengabuzima DP noneho dutangiza itandukaniro hanyuma rero kuva kuri telogene kugera kuri anagen.Sign-Ibimenyetso bya Catenin ni ingenzi mu mikurire yumuntu no kumera kumera.
Indi nzira yerekanwe muri DP ni ugukora ibimenyetso bidasanzwe bigengwa na kinase (ERK) na protein kinase B (Akt) byerekana iterambere ryimibereho kandi ikarinda apoptose.
Uburyo busobanutse neza PRP iteza imbere umusatsi ntabwo byumvikana neza.Kugira ngo hamenyekane uburyo bushoboka burimo, Li n'abandi, bakoze ubushakashatsi bwateguwe neza kugira ngo hakorwe ubushakashatsi ku ngaruka za PRP ku mikurire y’imisatsi ukoresheje vitro no muri moderi ya vivo.Muri moderi ya vitro, PRP ikora yakoreshejwe kuri selile ya DP yabantu yabonetse kuruhu rusanzwe rwumuntu.Ibisubizo byerekanaga ko PRP yongereye ikwirakwizwa ryingirabuzimafatizo za DP mu gukora ibimenyetso bya ERK na Akt, biganisha ku ngaruka zo kurwanya antapoptotique.PRP kandi yongereye ibikorwa β-catenin na imvugo ya FGF-7 muri selile DP.Kubijyanye na moderi ya vivo, imbeba zatewe na PRP zikora zerekanye byihuta bya telogene-kuri-anagen ugereranije nitsinda rishinzwe kugenzura.
Vuba aha, Gupta na Carviel basabye kandi uburyo bwogukora ibikorwa bya PRP ku mitsi y’abantu birimo "gusohora Wnt / β-catenin, ERK, na Akt byerekana inzira zitera kubaho kubaho, gukwirakwizwa, no gutandukana."
GF imaze guhuza umunyamakuru wa GF yakira, ibimenyetso bikenewe kugirango imvugo yayo itangire.GF-GF reseptor ikora imvugo ya signal ya Akt na ERK.Gukora kwa Akt bizahagarika inzira 2 zinyuze muri fosifora: (1) glycogene synthase kinase-3β itera kwangirika kwa β-catenin, na (2) Bcl-2 ifitanye isano na poropagande y'urupfu, ishinzwe gutera apoptose.Nkuko byavuzwe nabanditsi, PRP irashobora kongera imitsi,irinde apoptose, kandi wongere igihe cyicyiciro cya anagen.
Igihe cyo kohereza: Kanama-24-2022